Rune Factory 4 Special: Complete Guide To Medicine

Just as you can craft your own equipment and cook your own meals, you can also mix up your own medicine in Rune Factory 4. In fact, with the Chemistry Set you can be so self-reliant that you even make up special fertilizers for all of your farming needs.

It won't be far into the game that you start making your own supplies and improving your chemistry skill. Not only will this help you survive on your perilous journeys outside Selphia, but it can even be quite the handy money-making strategy!

Chemistry Basics

Once you have acquired the appropriate license via an order, you can purchase Chemistry Labs from either Jones or Nancy when they are working at the clinic. This will cost you some gold, some lumber, and some material stone.

Once you have the Chemistry Set installed you can start making restorative items, farming items, cooking ingredients, and eventually even stat boosters. The recipes for these items are listed in the tables below. When an ingredient is listed in italics, that means you can use any item of that ingredient's category.

When using the Chemistry Set, you will use Rune Points (RP) whenever you attempt a recipe. If the item's level is higher than your chemistry level, it will cost more RP to attempt to make it and there is a chance the attempt could outright fail – this will leave you with an Object X, a mysterious item that can be surprisingly useful.

You can learn recipes in-game by consuming Medicine Bread bought from Porcoline or acquired from festivals. Alternatively, you could follow the recipes listed in this guide by selecting the "Do not use recipe" option, though it costs considerably more RP the first time you make something this way.

Restorative Items

ItemLevelRecipe
Recovery Potion3Medicinal Herb, Green Grass
Roundoff13Black Grass, Black Grass
Recovery Potion15Blue Grass
Para-Gone18Indigo Grass, Indigo Grass
Healing Potion20Medicinal Herb, Red Grass
Cold Medicine22Orange Grass, Toyherb
Antidote Potion25Antidote Grass, Toyherb
Roundoff28Moondrop
Para-Gone31Pink Cat
Cold Medicine32Charm Blue
Mystery Potion33Medicinal Herb, White Grass
Antidote Potion38Cherry Grass
Healing Potion40Pom-Pom Grass
Magical Potion45Medicinal Herb, Elli Leaves
Formuade46Heavy Spice, Lamp Grass, Ironleaf, Powders and Spores, Liquids
Mystery Potion60Autumn Grass
Formuade65Hot-Hot Fruit
Magical Potion70Fireflower
Invinciroid76Noel Grass, Emery Flower, Autumn Grass, Hot-Hot Fruit, Formuade
Invinciroid86Giant Hot-Hot Fruit, Formuade
Love Potion87Emery Flower, Pink Melon, Strawberry, Honey, Hot-Hot Fruit, Grape Liqueur
Love Potion97Great Emery Flower

Cooking Items

ItemLevelIngredients
Sweet Powder5Apple
Sour Drop7Orange
Mixed Herbs8Green Grass, Toyherb
Heavy Spice10Purple Grass

Farming Items

ItemLevelRecipe
No Rot α26Withered Grass, Toyherb
Formula A29Withered Grass, Blue Grass, Black Grass
Wettable Powder30Charm Blue, Cherry Grass
Greenifier34Withered Grass, Indigo Grass, Moondrop Flower
Formula B41Yellow Grass, Pink Cat, 4-Leaf Clover
No Rot ß50Withered Grass, Red Grass, 4-Leaf Clover
Minimizer53Ironleaf
Giantizer57Lamp Grass
Greenifier+64Withered Grass, Orange Grass, Corn
Formula C72White Grass, Fireflower, Corn

Stat Boosters

ItemLevelRecipe
The Protein80Red Crystal, Red Crystal, Spinach, Powders and Spores, Liquids
Intelligencer82White Crystal, White Crystal, Eggplant, Powders and Spores, Liquids
Vital Gummi83Blue Crystal, Blue Crystal, Bok Choy, Powders and Spores, Liquids
Heart Drink85Green Crystal, Green Crystal, Ironleaf, Powders and Spores, Liquids
The Protein90Big Red Crystal
Intelligencer92Big White Crystal
Vital Gummi93Big Blue Crystal
Heart Drink95Big Green Crystal
Leveliser96Emery Flower, 4-Leaf Clover, Noel Grass, Autumn Grass, Fireflower, Hot-Hot Fruit
Leveliser99Great Emery Flower, Great 4-Leaf Clover

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